TRANSCRIPTOME ANALYSIS OF SKIN FIBROBLASTS WITH DOMINANT NEGATIVE COL3A1 MUTATIONS PROVIDES MOLECULAR INSIGHTS INTO THE ETIOPATHOLOGY OF VASCULAR EHLERS-DANLOS SYNDROME.

Vascular Ehlers-Danlos syndrome (vEDS) is a dominantly inherited connective tissue disorder caused by mutations in the COL3A1 gene that encodes type III collagen (COLLIII), which is the major expressed collagen in blood vessels and hollow organs.The majority of disease-causing variants in COL3A1 are glycine substitutions and in-frame splice mutatio

The purpose of this article is to present the work done on the implementation of rules for gliders in a game Hopper of life with a non-regular network with boundaries.First of all, we will recall the basic principle of the game of life by mentioning some structures that appear regularly and are very important as gliders.We will improve the accuracy

As a no-disturbance integrated-retrofitting technique, an external rocking frame was widely used on reinforced concrete (RC) structures.Yet, with the increasing demand for seismic strengthening of existing buildings, it has become a concern to evaluate the seismic strengthening schemes based on seismic resilience.Firstly, the dynamic equation of th